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You may have been thinking about taking Antabuse for quite some time The disulfiram-alcohol reaction begins typically about 10 to 30 minutes after you drink alcohol. Do not drive a car or operate machinery until you know how this drug affects you and you get clearance from your doctor Disulfiram, sold under the brand name Antabuse and Antabus, is a prescription drug to support complete abstinence from alcohol. Alan Ali and 3 doctors agree 1 thank A Verified Doctor answered Addiction Medicine 50 years experience. Antabuse has some central nervous system effects Yes: Antabuse ( disulfiram) is a medication that needs a doctor's prescription. It is possible to obtain those medications from online pharmacies without a doctor's prescription but there's the risk that the pills you receive aren't the real thing Both naltrexone and Antabuse can be prescribed at Monument. Your doctor may occasionally change your dose to make sure you get the best results. 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